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Antiretroviral (ARV)

The extensive range of generic products marketed by Novagen Pharma (Pty) Ltd conform to strict international standards.
Further information is available on request. For full prescribing information refer to the approved Professional Information Leaflet.

Registration Number Trade Name Active Ingredient/Strength Dosage Form Schedule Pack size PIL
47/20.2.8/0504 Citenvir® Efavirenz 600 mg,
Emtricitabine 200 mg,
Tenofovir Disoproxil Fumarate 300 mg
Tabs S4 30
  • Patient Information Leaflet
    Adobe PDF, 59 KB
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A40/20.2.8/0562 Dozra 50 mg/5 ml Zidovudine 10 mg/ml Sol S4 240 ml
  • Patient Information Leaflet
    Adobe PDF, 73 KB
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41/20.2.8/0541 Erige 50 mg Efavirenz 50 mg Caps S4 30
  • Patient Information Leaflet
    Adobe PDF, 59 KB
    Download
41/20.2.8/0543 Erige 200 mg Efavirenz 200 mg Caps S4 90
  • Patient Information Leaflet
    Adobe PDF, 59 KB
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A40/20.2.8/0513 Erige 600 mg Efavirenz 600 mg Tabs S4 30
  • Patient Information Leaflet
    Adobe PDF, 58 KB
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41/20.2.8/0248 Invertron 300 mg Abacavir Sulphate 300 mg Tabs S4 60
  • Patient Information Leaflet
    Adobe PDF, 50 KB
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41/20.2.8/0386 Invertron 20 mg/ml Oral Solution Abacavir Sulphate 20 mg/ml Sol S4 240 ml
  • Patient Information Leaflet
    Adobe PDF, 50 KB
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A40/20.2.8/0561 Legram 10 mg/ ml Lamivudine 10 mg/ml Sol S4 240 ml
  • Patient Information Leaflet
    Adobe PDF, 69 KB
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A40/20.2.8/0376 Legram 150 mg Lamivudine 150 mg Tabs S4 60
  • Patient Information Leaflet
    Adobe PDF, 65 KB
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A40/20.2.8/0381 Lodiz Lamivudine 150 mg,
Zidovudine 300 mg
Tabs S4 60
  • Patient Information Leaflet
    Adobe PDF, 72 KB
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44/20.2.8/0086 Tyricten® 200/300 mg Emtricitabine 200 mg,
Tenofovir Disoproxil Fumarate 300 mg
Tabs S4 30
  • Patient Information Leaflet
    Adobe PDF, 53 KB
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A40/20.2.8/0382 Viropon 200 mg Nevirapine Hemihydrate 200 mg Tabs S4 60
  • Patient Information Leaflet
    Adobe PDF, 95 KB
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A40/20.2.8/0490 Viropon 50 mg/5 ml Nevirapine 10 mg/ml Sol S4 240 ml
  • Patient Information Leaflet
    Adobe PDF, 42 KB
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44/20.2.8/0307 Zefin 300 mg Tenofovir Disoproxil Fumarate 300 mg Tabs S4 30
  • Patient Information Leaflet
    Adobe PDF, 55 KB
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More about: Antiretroviral (ARV)

Antiretroviral drugs are medications for the treatment of infection by retroviruses, primarily HIV. When several of such drugs, typically three or four, are taken in combination, the approach is known as Highly Active Antiretroviral Therapy, or HAART.

Antiretroviral Drugs

Definition

Antiretroviral drugs inhibit the reproduction of retroviruses—viruses composed of RNA rather than DNA. The best known of this group is HIV, human immunodeficiency virus, the causative agent of AIDS. 1

Purpose

Antiretroviral agents are virustatic agents which block steps in the replication of the virus. The drugs are not curative; however continued use of drugs, particularly in multi-drug regimens, significantly slows disease progression.1

Description

There are three main types of antiretroviral drugs, although only two steps in the viral replication process are blocked. Nucleoside analogues, or nucleoside reverse transcriptase inhibitors (NRTIs), such as didanosine, lamivudine, stavudine, zalcitabine, and zidovudine, act by inhibiting the enzyme reverse transcriptase. Because a retrovirus is composed of RNA, the virus must make a DNA strand in order to replicate itself. Reverse transcriptase is an enzyme that is essential to making the DNA copy. The nucleoside reverse transcriptase inhibitors are incorporated into the DNA strand. This is a faulty DNA molecule that is incapable of reproducing.

The non-nucleoside reverse transcriptase inhibitors (NNRTIs), such as delavirdine, loviride, and nevirapine act by binding directly to the reverse transcriptase molecule, inhibiting its activity.

Because HIV mutates readily, the virus can develop resistance to single drug therapy. However, treatment with drug combinations appears to produce a durable response. Proper treatment appears to slow the progression of HIV infections and reduce the frequency of opportunistic infections. One of the most notable advances in recent years has been the success of highly active antiretroviral therapy (HAART). This multidrug approach reduced the risk of opportunistic infections in persons with HIV/AIDS and slowed the progression of the disease and death.1

Reference:

  1. http://medical-dictionary.thefreedictionary.com/Antiretroviral+Drugs (2 May 2019)

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